Publications

Only selected representative papers were presented.

  • 2026
  • Yi Y*, Li Y*, Wang R, Yu X, Liu Q, Yum C, Zhang Y, Qiao Y, Szczepanski A, Wu S, Li Q, Fazli L, Shen J, Wang X, Li X, Mu P, Schaeffer EM, Hundley HA, Niu H, Chinnaiyan AM, Wang L, Shi J, Jin J, Dong X, Zhao W, Chen K, Cao Q. A dual role of EZH2 in regulating A-to-I RNA editing and mRNA stability through ADAR. Nature Communications. 2026 Mar 26. doi: 10.1038/s41467-026-71207-3. PMID: 41882000.
  • 2025
  • Yi Y* (first and co-corresponding author), Fry J*, Yum C*, Wang R, Wu S, Narayan S, Liu Q, Zhang X, Oo HZ, Xie N, Li Y, Gao X, Yu X, Hu X, Li Q, Keseroglu K, Özbudak EM, Abdulkadir SA, Chen K, Jin J, Zhao JC, Dong X, Arango D, Yang R, Cao Q. EZH2 crosstalk with RNA methylation promotes prostate cancer progression through modulation of m6A autoregulation pathway. Journal of Clinical Investigation. 2025 Nov 18;136(2):e195840. doi: 10.1172/JCI195840. PMID: 41252201; PMCID: PMC12807473.
  • 2024
  • Li Y*, Yi Y* (co-first author), Gao X, Wang X, Zhao D, Wang R, Zhang LS, Gao B, Zhang Y, Zhang L, Cao Q, Chen K. 2′-O-methylation at internal sites on mRNA promotes mRNA stability. Molecular Cell. 2024 Jun 20;84(12):2320-2336.e6. doi: 10.1016/j.molcel.2024.04.011. PMID: 38906115; PMCID: PMC11196006.
  • 2023
  • Gao X*, Yi Y* (co-first author), Lv J*, Li Y, Arulsamy K, Babu SS, Bruno I, Zhang L, Cao Q, Chen K. Low RNA stability signifies strong expression regulatability of tumor suppressors. Nucleic Acids Research. 2023 Nov 27;51(21):11534-11548. doi: 10.1093/nar/gkad838. PMID: 37831104; PMCID: PMC10681714.
  • Li Y*, Yi Y* (co-first author), Lv J, Gao X, Yu Y, Babu S, Bruno I, Zhao D, Xia B, Peng W, Zhu J, Chen H, Zhang L, Cao Q, Chen K. Low RNA stability signifies increased post-transcriptional regulation of cell identity genes. Nucleic Acids Res. 2023 May 1:gkad300. doi: 10.1093/nar/gkad300. PMID: 37125636.
  • 2022
  • Yi Y*, Li Y*, Li C*, Wu L, Zhao D, Li F, Fazli L, Wang R, Wang L, Dong X, Zhao W, Chen K, Cao Q. Methylation-dependent and -independent roles of EZH2 synergize in CDCA8 activation in prostate cancer. Oncogene. 2022 Mar;41(11):1610-1621. doi: 10.1038/s41388-022-02208-x. Epub 2022 Jan 29. PMID: 35094010; PMCID: PMC9097394.
  • 2021
  • Yi Y*, Li Y*, Meng Q*, Li Q, Li F, Lu B, Shen J, Fazli L, Zhao D, Li C, Jiang W, Wang R, Liu Q, Szczepanski A, Li Q, Qin W, Weiner AB, Lotan TL, Ji Z, Kalantry S, Wang L, Schaeffer EM, Niu H, Dong X, Zhao W, Chen K, Cao Q. A PRC2-independent function for EZH2 in regulating rRNA 2′-O methylation and IRES-dependent translation. Nature Cell Biology. 2021 Apr;23(4):341-354. doi: 10.1038/s41556-021-00653-6. Epub 2021 Apr 1. PMID: 33795875; PMCID: PMC8162121.
  • Before 2021
  • Li F*, Yi Y* (co-first author), Miao Y*, Long W, Long T, Chen S, Cheng W, Zou C, Zheng Y, Wu X, Ding J, Zhu K, Chen D, Xu Q, Wang J, Liu Q, Zhi F, Ren J, Cao Q, Zhao W. N6-Methyladenosine Modulates Nonsense-Mediated mRNA Decay in Human Glioblastoma. Cancer Research. 2019 Nov 15;79(22):5785-5798. doi: 10.1158/0008-5472.CAN-18-2868. Epub 2019 Sep 17. PMID: 31530567; PMCID: PMC7360104. (This work was featured on The Best of AACR Journal 2021, a collection of the most-cited research articles published by American Association for Cancer Research)

Complete List of Dr. Yang Yi’s Published Work can be found in Google scholar.